An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice

Abstract

AbstractBackground:extract (DAE) is used traditionally in Ghana for the management of psychosis. The present study aimed at providing pharmacological evidence for its ethnomedical use by testing the hypothesis that an ethanolic extract ofMethods:The primary behavioral effects of DAE on the central nervous system of mice were investigated using Irwin’s test paradigm. Novelty-induced and apomorphine-induced locomotor and rearing behaviors in mice were explored in an open-field observational test system. Apomorphine-induced cage climbing test in mice was used as the antipsychotic animal model. The ability of DAE to induce catalepsy and enhance haloperidol-induced catalepsy was also investigated in mice.Results:The DAE produced sedation, cholinergic-, and serotonergic-like effects in mice when evaluated using the Irwin’s test. No lethality was observed after 24 h post-treatment. The LDConclusions:The ethanolic extract of