Hepatoprotective effects of Vaccinium arctostaphylos against CCl4-induced acute liver injury in rats

Abstract

AbstractBackground:This study was carried out to evaluate the antioxidant and hepatoprotective effects ofMethods:Total phenolic and total flavonoid contents as well as antioxidant activity of V.a were determined. Extracts of V.a at doses of 200 and 400 mg/kg were administered by oral gavage to rats once per day for 7 days and then were given an intraperitoneal injection of 1 mL/kg CClResults:The obtained results showed that V.a had strong antioxidant activity. Treatment of rats with V.a blocked the CClConclusions:These findings suggested that V.a may be useful in the treatment and prevention of hepatic injury induced by CCl