Author:
Oboh Ganiyu,Adebayo Adeniyi Abiodun,Ademosun Ayokunle Olubode,Boligon Aline August
Abstract
AbstractBackground:andMethods:The effects of the extracts on important enzymes (PDE-5 and arginase) linked with ED and pro-oxidants (FeResults:The results showed that both extracts inhibited PDE-5 and arginase activities in a dose-dependent manner. Inhibitory property ofConclusions:The ability of the extracts to inhibit PDE-5, arginase and pro-oxidant induced lipid peroxidation, and chelate metal might suggest their folkloric use for the management of ED.
Subject
Drug Discovery,Pharmacology,General Medicine,Physiology
Reference96 articles.
1. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships;Biochem Pharmacol,2004
2. Inhibition of Leishmania (Leishmania) amazonensis and rat arginases by green tea EGCG, (+)-catechin and (-)-epicatechin: a comparative structural analysis of enzyme-inhibitor interactions;PLoS One,2013
3. Hepatoprotective potential of Caesalpinia crista against iron-overload-induced liver toxicity in mice;Evidence-Based Compl Alt Med,2012
4. Role of oxidative stress and antioxidants in Peyronie’s disease;Int J Impo Res,2002
Cited by
48 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献