Smart NIR-light and pH responsive doxorubicin-loaded GNRs@SBA-15-SH nanocomposite for chemo-photothermal therapy of cancer-Reference-Cited by-同舟云学术

Smart NIR-light and pH responsive doxorubicin-loaded GNRs@SBA-15-SH nanocomposite for chemo-photothermal therapy of cancer

Published:2021-08-13 Issue:12 Volume:10 Page:3303-3319
ISSN:2192-8614
Container-title:Nanophotonics
language:en
Short-container-title:

Author:

Deinavizadeh Maryam¹,Kiasat Alireza¹²^ORCID,Hooshmand Nasrin³^ORCID,Shafiei Mohammad⁴,Sabaeian Mohammad⁵⁶,Mirzajani Roya¹^ORCID,Zahraei Seyed Mohammadsaleh⁴,Labouta Hagar I.⁷^ORCID,El-Sayed Mostafa A.³^ORCID

Affiliation:

1. Department of Chemistry , Faculty of Science, Shahid Chamran University of Ahvaz , Ahvaz , Iran

2. Petroleum Geology and Geochemistry Research Center (PGGRC), Shahid Chamran University of Ahvaz , Ahvaz , Iran

3. Laser Dynamics Laboratory , School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta , GA , 30332 , USA

4. Department of Biology , Faculty of Science, Shahid Chamran University of Ahvaz , Ahvaz , Iran

5. Department of Physics , Faculty of Science, Shahid Chamran University of Ahvaz , Ahvaz , Iran

6. Center for Research on Laser and Plasma, Shahid Chamran University of Ahvaz , Ahvaz , Iran

7. College of Pharmacy , Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB , Canada

Abstract

Abstract We designed novel biocompatible nanocomposite composed of gold nanorods coated with rod-like mesoporous silica SBA-15-SH particles, (GNRs@SBA-15-SH) as a new synergistic therapeutic device to deliver heat and drug to cancer cells for tumor eradication. For this purpose, doxorubicin (DOX) was loaded into GNRs@SBA-15-SH nanocomposites and studied their photothermal therapy, chemotherapy and the combined effect on the ablation of A549 cells in vitro using human lung cancer cells, A549. The results demonstrate the high photothermal efficacy of gold nanorods loaded into the nanocomposite, the thermo-responsive properties of GNRs@SBA-15-SH, the high loading capacity of DOX into the GNRs@SBA-15-SH and its biocompatibility. Synergistic chemo-photothermal of the GNRs@SBA-15-SH/DOX nanocomposite in the eradication of cancer cells under laser irradiation (808 nm), demonstrates the high potential of therapeutic efficacy of this combined therapy over monotherapies.

Publisher

Walter de Gruyter GmbH

Subject

Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials,Biotechnology

Link

https://www.degruyter.com/document/doi/10.1515/nanoph-2021-0207/pdf

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