Capillary-assisted flat-field formation: a platform for advancing nanoparticle tracking analysis in an integrated on-chip optofluidic environment

Author:

Gui Fengji1ORCID,Foerster Ronny1,Wieduwilt Torsten1,Zeisberger Matthias1,Kim Jisoo1,Schmidt Markus A.123

Affiliation:

1. The Department of Fiber Photonics , Leibniz Institute of Photonic Technology , Albert-Einstein-Street 9, 07745 Jena , Germany

2. Abbe Center of Photonics and Faculty of Physics, Friedrich-Schiller-University Jena , Max-Wien-Platz 1, 07743 Jena , Germany

3. Otto Schott Institute of Materials Research, Friedrich Schiller University Jena , Fraunhoferstr. 6, 07743 Jena , Germany

Abstract

Abstract Here, we present the concept of flat-field capillary-assisted nanoparticle tracking analysis for the characterization of fast diffusing nano-objects. By combining diffusion confinement and spatially invariant illumination, i.e., flat-fields, within a fiber-interfaced on-chip environment, ultra-long trajectories of fast diffusing objects within large microchannels have been measured via diffraction-limited imaging. Our study discusses the design procedure, explains potential limitations, and experimentally confirms flat-field formation by tracking gold nanospheres. The presented concept enables generating flat-fields in a novel on-chip optofluidic platform for the characterization of individual nano-objects for fundamental light/matter investigations or applications in bioanalytics and nanoscale material science.

Funder

Deutsche Forschungsgemeinschaft

China Scholarship Council

Publisher

Walter de Gruyter GmbH

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