Chelation Reactions of Adenine

Abstract

Chelation reactions of the antimitotic drug, 6-amino-purine (adenine; abbr. ADN) with the metal ions: Be(II), Al(III), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Pb(II), and UO2(II) have been investigated in aqueous solution at 30° using Bjerrum-Calvin pH titration technique. The formation constants have been determined at various ionic concentrations, and have been extrapolated to zero ionic strength to get the thermodynamic values of the constants.