Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging-Reference-Cited by-同舟云学术

Radioiodination and biological evaluation of landiolol as a tracer for myocardial perfusion imaging: preclinical evaluation and diagnostic nuclear imaging

Published:2018-09-01 Issue:12 Volume:106 Page:1001-1008
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Sanad M. H.¹,Farag A. B.²,Motaleb M. A.³

Affiliation:

1. Labeled Compounds Department , Hot Labs Center, Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt , Tel.: 00201006131628, Fax: 0020225180527, E-mail:

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy , Ahram Canadian University , Giza , Egypt

3. Labeled Compounds Department , Hot Labs Center, Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

Abstract

Abstract The present work has assessed the ability and competency of radioiodinated landiolol that is considered a potential cardio selective imaging agent. Landiolol was radiosynthesized with [131I] using chloramine-T (Ch-T) as an oxidizing agent. To give high radiochemical yield of the [131I]landiolol reaching values of 98% with high stability up to 48 h. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoresis and high performance liquid chromatography (HPLC). Biodistribution studies indicated that [131I]landiolol gave high heart uptake ratio of [45.0±0.19% ID/g at 2 min post injection (p.i.)]. Therefore, [131I]landiolol could be considered as a novel tracer to image heart with high heart/blood ratio within 60 min.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2018-2980/pdf

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