Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure-Reference-Cited by-同舟云学术

Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure

Published:2019-06-18 Issue:2 Volume:108 Page:105-111
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Shchepina Nadezhda E.¹,Avrorin Viktor V.²,Badun Gennadii A.³,Shurov Sergey N.⁴,Shchepin Roman V.⁵⁶

Affiliation:

1. Laboratory of Radiochemistry , Institute of Natural Sciences of Perm State University , 4, Genkel St. , Perm 614990 , Russia

2. Chemistry Department , Saint-Petersburg State University , 7/9, Universitetskaya nab. , Saint-Petersburg 199034 , Russia

3. Chemistry Department , M.V. Lomonosov Moscow State University , 1, Leninskie Gory , Moscow 119991 , Russia

4. Chemistry Department , Perm State University , 15, Bukirev St. , Perm 614990 , Russia

5. Department of Radiology , Vanderbilt University Institute of Imaging Science (VUIIS) , Nashville, TN 37232 , USA

6. Department of Chemistry and Applied Biological Sciences , South Dakota School of Mines and Technology , Rapid City, SD 57701 , USA

Abstract

Abstract Quinazoline derivatives are well known to have a diverse array of therapeutic activities. Unfortunately, “classic” chemical synthesis does not provide an opportunity for the formation of N-phenyl quaternary 1,3-diazinium compounds. A devised nuclear-chemical method of synthesis based on chemical effects of nuclear transformations enables a new way of the direct nitrogen atom phenylation by the nucleogenic (generated by tritium β-decay) phenyl cations in 1,3-diazines, furnishing, based on our prediction, formation of previously unknown derivatives with N-phenyl quaternary quinazolinium scaffold.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2018-2970/pdf

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