Affiliation:
1. Turku PET Centre, Radiopharmaceutical Chemistry Laboratory and Accelerator Laboratory, Porthaninkatu 3, FI-20500 Turku, Finland
Abstract
Abstract
Electrophilic radiofluorination was successfully carried out in the early years of PET radiochemistry due to its ease and fast reaction
speed. However, at the present, the use of electrophilic methods is limited due to low specific activity (SA). Post-target produced
[18F]F2 has significantly higher SA compared to other electrophilic approaches, and it has been used in the production of
clinical PET radiopharmaceuticals at the Turku PET Centre for years. Here, we summarize the synthesis and use of these
radiopharmaceuticals, namely [18F]FDOPA, [18F] CFT, [18F]EF5 and [18F]FBPA.
Subject
Physical and Theoretical Chemistry
Cited by
9 articles.
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