99Mo/99mTc radioisotope generator based on adsorption of 99Mo (VI) on cerium (IV) molybdate column matrix
Author:
El-Said Hassan1, Ramadan Hala1, Abbas Mahmoud1, El-Hashash Maher2
Affiliation:
1. Radioactive Isotopes and Generators Department , Hot Labs. Center, Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt 2. Chemistry Department, Faculty of Science , Ain Shams University , Cairo , Egypt
Abstract
Abstract
Based on neutron activated 99Mo, a procedure for preparation of 99Mo/99mTc radioisotope generator was developed. Batch equilibration method was used to investigate the sorption behavior of Mo (VI) (10−4 M) in chloride and nitrate solutions on cerium (IV) molybdate gel matrix using 99Mo radiotracer. The breakthrough sorption capacity of cerium molybdate gel matrix for 99Mo (VI) (3×10−2 M) were found to be 0.54 mmol/g of the sorbent [1 g column (0.6 cm i.d.)]. Elution performance of the generated 99mTc from cerium molybdate-99Mo chromatographic column was investigated as a function of inside diameter of the column, amount of the bed matrix and flow rate of the eluent. Based on the obtained results, 99Mo/99mTc radioisotope generator was prepared based on adsorption of neutron activated 99Mo (VI) of low specific activity onto chromatographic columns packed with 5 g cerium molybdate gel matrix. The radioactivity of 99mTc is periodically eluted with 10 mL 0.9% NaCl solution at a flow rate of 1 mL/min. Elution yield of 78±5% was obtained with high chemical, radionuclidic (99Mo breakthrough 1×10−3±0.3×10−3%) and radiochemical purity (97±2%).
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
Reference36 articles.
1. Garimella, V. S. R., Colombetti, L. G.: Radiotracers for Medical Applications. CRC Press, Boca Raton, Florrida (1983). 2. Lagunas-Solar, M. C., Kiefer, P. M., Carvacho, O. F., Lagunas, C. A., Ya, P. C.: Cyclotron production of NCA 99mTc and 99Mo: an alternative non-reactor supply source of instant 99mTc and 99Mo/99mTc generators. Appl. Radiat. Isot. 42(7), 643 (1991).10.1016/0883-2889(91)90035-Y 3. Scholten, B., Lambrecht, R. M., Cogenau, M., Vera Ruiz, H., Qaim, S. M.: Excitation functions for the cyclotron production of 99mTc and 99Mo. Appl. Radiat. Isot. 51(1), 69 (1999).10.1016/S0969-8043(98)00153-5 4. Ganon, K., Benard, F., Kovacs, M., Ruth, T. J., Schaffer, P., Wilson, J. S., McQuarrie, S. A.: Cyclotron production of 99mTc: experimental measurement of the 100M(p,x)99Mo, 99mTc and 99gTc excitation functions from 8 to 18 MeV. Nucl. Med. Biol. 38, 907 (2011).10.1016/j.nucmedbio.2011.02.010 5. Guerin, B., Tremblay, S., Rodrigue, S., Rousseau, J. A., Dumulon-Perreault, V., Lecomte, R., Van Lier, J. E., Zyuzin, A.: Cyclotron production of 99mTc: an approach to the medical isotope crisis. Nucl. Med. 51, 13N (2010).
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|