Affiliation:
1. Nuclear Science and Technology Research Institute (NSTRI), Box 14395-836, Tehran, Iran
2. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Abstract
Introduction: Recent studies show that porphyrin derivatives have interesting pharmacological and photodynamic properties and
wide range of usage in photodynamic therapy treatment. This study describes the preparation, biodistribution and absorbed dose
prediction of [111In] labeled 5, 10, 15, 20-tetra phenyl porphyrin (TPP) in human organs, based on rats' biodistribution
data. Methods: Five rats were sacrificed at each exact time intervals (2, 4 and 24 h post injection) and the
percentage of injected dose per gram of each organ was measured by direct counting from rats data from 12 harvested organs. The Medical
Internal Radiation Dose (MIRD) formulation was applied to extrapolate from rats to human and to project the absorbed radiation dose for
various organs in humans. Results: From rat data we estimated that injection of [111In] TPP into the humans would
result in an estimated effective absorbed dose of 0.09 mSv/MBq in the whole body. While the highest effective absorbed dose
for 111In-TPP was in the heart wall (0.22 mSv), the organs that received the next highest doses were the Kidneys
(0.06 mSv), thymus (0.04 mSv) and lungs (0.03 mSv). Conclusions: The skin dose will four
times higher compare to the other 111In compounds, which was due to magnificent skin uptakes. According to the fast
wash-out, tumor avidity and the short half-life, [111In] can be a suitable candidate for labeling of photo dynamic therapy
(PDT) agents as a tracer for accurate biological evaluation of other PDT agents such as Photofrin and its homologs.
Subject
Physical and Theoretical Chemistry
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献