Radioiodinated famotidine as a new highly selective radiotracer for peptic ulcer disorder detection, diagnostic nuclear imaging and biodistribution-Reference-Cited by-同舟云学术

Radioiodinated famotidine as a new highly selective radiotracer for peptic ulcer disorder detection, diagnostic nuclear imaging and biodistribution

Published:2016-12-20 Issue:5 Volume:105 Page:389-398
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Sanad M. H.¹,Salama Dina H.²,Marzook F. A.³

Affiliation:

1. Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

2. Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

3. Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, Cairo, Egypt

Abstract

Abstract Famotidine was labeled with iodine-125 to obtain 125I-famotidine (125I-fam) as an agent for ulcer imaging. The radiochemical yield of 125I-famotidine reached approximately 98.5 ± 0.23% at optimum conditions of pH, oxidizing agent, reaction time and the amount of substrate. 125I-fam was stable for 48 h. Different chromatographic techniques were used to determine the radiochemical yield and purity. Intravenous biodistribution studies of 125I-fam revealed high concentration in the stomach ulcer, reaching about 65.9 ± 0.28% of the total injected dose at 30 min post injection. This concentration of 125I-fam in stomach ulcer makes this agent promising for stomach ulcer imaging.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2016-2683/pdf

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