Radioiodinated celiprolol as a new highly selective radiotracer for β1-adrenoceptor-myocardial perfusion imaging-Reference-Cited by-同舟云学术

Radioiodinated celiprolol as a new highly selective radiotracer for β1-adrenoceptor-myocardial perfusion imaging

Published:2018-04-27 Issue:9 Volume:106 Page:751-757
ISSN:2193-3405
Container-title:Radiochimica Acta
language:en
Short-container-title:

Author:

Sanad M. H.¹,Talaat H. M.²,Ibrahim I. T.²,Saleh G. M.³,Abouzeid L. A.⁴

Affiliation:

1. Labeled Compounds Department , Hot Labs Center , Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt , E-mail:

2. Labeled Compounds Department , Hot Labs Center , Egyptian Atomic Energy Authority , P.O. Box 13759 , Cairo , Egypt

3. Health Radiation Research Department (Radiodiagnosis Unit) , National Center for Radiation Research and Technology, Atomic Energy Authority , Cairo , Egypt

4. Department of Organic Pharmaceutical Chemistry , Faculty of Pharmacy, Delta University , Mansoura , Egypt

Abstract

Abstract The present study was oriented to synthesis radioiodinated celiprolol (Cel) for a potential cardiac imaging. Celiprolol has been labeled using 125I with chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize the iodination. The biological distribution indicates the suitability of radioiodinated Cel as a novel tracer to image heart.

Publisher

Walter de Gruyter GmbH

Subject

Physical and Theoretical Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/ract-2017-2903/pdf

Reference27 articles.

1. Stoschitzky, K., Zernig, G., Lindne, W.: Racemic beta-blockers – fixed combinations of different drugs. J. Clin. Basic Cardiol. 1, 1 (1998).

2. Reddy, M. N., Rehana, T., Ramakrishna, S., Chowdary, K. P. R., Diwan, P. V.: β-Cyclodextrin complexes of celecoxib: molecular-modeling, characterization, and dissolution studies. AAPS Pharm. Sci. 6, 68 (2004).10.1208/ps060107

3. Javier, C., Llanos, C. M., David, D., Carlos, J., Ramo, N.: Chiral discrimination of ibuprofen isomers in b-cyclodextrin inclusion complexes: experimental (NMR) and theoretical (MD, MM/GBSA) studies. Tetrahedron 62, 4162 (2006).10.1016/j.tet.2006.02.010

4. Dodziuk, H., Komiski, W., Lukin, O., Sybilska, D.: NMR manifestations and molecular dynamics modeling of chiral recognition of α-pinenes by α-cyclodextrin. J. Mol. Struct. 523, 205 (2000).10.1016/S0022-2860(99)00409-3

5. Interian, A., Zaman, L., Velez-Robinson, E., Kozlovskis, P., Castel-lanos, A., Myerburg, R. J.: Paired comparisons of efficacy of intravenous and oral procainamide in patients with induciblesustained ventricular tachyarrhythmias. Am. Coll. Cardiol. 17, 1581 (1991).10.1016/0735-1097(91)90651-O

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analyzing Paraben Degradation in Parenteral Formulations with High-Performance Liquid Chromatography;Current Pharmaceutical Analysis;2024-08-13

2. Assessment of Antibacterial Fabric Nanocomposites Utilizing Polymer Blend and Silver/Copper Oxide after Irradiation with Electron Beam;Egyptian Journal of Chemistry;2024-04-15

3. Facile one-pot strategy for radiocoplexation of [99mTc]-nitrido-nebracetam for brain imaging: Biological evaluation, Optimized chromatographic separation and labeling conditions.;Egyptian Journal of Chemistry;2024-01-24

4. Facile one-pot strategy for radiopreprationof radioiodinated phenylpiracetam as a new highly selective radiotracer for brainimaging;Egyptian Journal of Chemistry;2024-01-24

5. Radioiodination and Biological Evaluation of Novel Quinoline Derivative for Infective Inflammation Diagnosis;Pharmaceutical Chemistry Journal;2023-10