In-vitro anticancer profile of recent ruthenium complexes against liver cancer

Author:

Shahzad Khurram1,Asad Mohammad23,Asiri Abdullah M.23,Irfan Muhammad1,Iqbal Muhammad Adnan14ORCID

Affiliation:

1. Department of Chemistry , University of Agriculture , Faisalabad , 38000 , Pakistan

2. Center of Excellence for Advanced Materials Research (CEAMR) , King Abdulaziz University , P.O. Box 80203 , Jeddah 21589 , Saudi Arabia

3. Chemistry Department , Faculty of Science, King Abdulaziz University , P.O. Box 80203 , Jeddah 21589 , Saudi Arabia

4. Organometallic and Coordination Chemistry Laboratory , University of Agriculture , Faisalabad , 38000 , Pakistan

Abstract

Abstract Ruthenium complexes are considered as the most favorable alternatives to traditional platinum-based cancer drugs owing to their acceptable toxicity level, selectivity, variant oxidation states and ability to treat platinum-resistant cancer cells. They have similar ligand exchange kinetics as platinum drugs but can be tailored according to our desire by ligands influence. In the current study, we illustrate the in-vitro anticancer profile of some ruthenium complexes (2016–2021) against human hepatocellular carcinoma (HepG2). The anticancer activity of ruthenium complexes is determined by comparing their IC50 values with one another and positive controls. Fortunately, some ruthenium complexes including 3, 4, 6, 14, 15, 20, 42, and 48 exhibit surpassed in-vitro anticancer profile than that of positive controls promising as potential candidates against liver cancer. We also explored the structure-activity relationship (SAR) which is a key factor in the rational designing and synthesis of new ruthenium drugs. It covers the factors affecting anticancer activity including lipophilicity, planarity, area and bulkiness, the steric influence of different ligands, and electronic effects induced by ligands, stability, aqueous solubility and bioavailability to the target sites. The data reported here will provide strong support in the plausible design and synthesis of ruthenium anticancer drugs in the upcoming days.

Funder

King Abdulaziz University

Publisher

Walter de Gruyter GmbH

Subject

Inorganic Chemistry

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Ruthenium complexes for breast cancer therapy;Reviews in Inorganic Chemistry;2023-07-28

2. Redox Reactions of Coordination Compounds in the Biomedical Environment;Fundamental and Biomedical Aspects of Redox Processes;2023-06-09

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