Experimental and molecular topology-based biological implications of Schiff base complexes: a concise review

Abstract

AbstractThis review is a gentle introduction toward Schiff bases with special attention to bioinorganic aspects. Depending on the nature of condensation moieties (ketonic or aldehydic) with primary amine, a large number of novel compounds are reported every year with applicability in various material science aspects. Herein, a burgeoning literature overview is presented to provide a salient discussion of the current status of these molecular systems. Schiff bases are designed depending on the particular desirable properties. For instance, to enlighten a biologically relevant molecule, it is always appreciated when a prepared compound shows biological membrane crossing and nucleic acid linking potential. Under such purview, the Schiff base functional group can serve as an enhancer of biomembrane traversing capability. In addition to various other catalytic aspects, the type of disease to be encountered also matters. Nowadays, theoretical chemistry is applied before synthesizing a compound of this sort and fruitful results are first depicted and, if found feasible, a suitable synthetic route is followed to synthesize Schiff base compounds. Molecular charge topology analysis under theoretical expression is analyzed generally to predict the biological relevance of a molecule.