Synthesis and Resolution of a New C2-Symmetric Chiral Bis-Aniline, trans-1,2-Bis(2-aminophenyl)cyclopentane

Abstract

New C2-symmetric trans-1,2-bis(2-aminophenyl)cyclopentanes 2a and 2b were synthesized in optically pure forms (99% ee) from the known racemic trans-1,2-bis(2-hydroxyphenyl)cyclopentane (3) by the conversion to its bis-triflate 4 followed by the Buchwald amination and resolution.