Author:
Arnold Luboš,Točík Zdeněk,Bradková Eliška,Hostomský Zdeněk,Pačes Václav,Smrt Jiří
Abstract
Preparation of solid supports with long aliphatic spacer for the oligonucleotide synthesis is described. Automated synthesis of oligodeoxyribonucleotides using in situ prepared methylchlorophosphite intermediates from amidine protected purine nucleosides is described. Phosphoramidite synthesis of oligodeoxyribonucleotides mediated by 1-methylimidazole trifluoromethanesulfonate is described. Novel isolation of crude oligonucleotides by ethanol precipitation of potassium salts is described.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
34 articles.
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