Potential anticonvulsants: 3-Chlorobenzophenone derivatives

Abstract

Reactions of 2-(2-iodoacetamido)-5-chlorobenzophenone with 2-amino-2-phenylethanol, 2-amino-1-phenylethanol, 3-amino-2-phenylpropanol, D-(+)-norpseudoephedrine, and 2-aminopropane-2-carbonitrile gave the 2-substituted N-(2-benzoyl-4-chlorophenyl)acetamides X-XIV. 2,3'-Dichlorobenzhydrol (XVI) and 2,3'-dichlorobenzhydryl chloride (XIX) were transformed to the ethers XVII and XVIII and to the amines XXI-XXIV. Compound XVI was oxidized to the ketone XXV which was transformed via the oxime XXVI to compound XXVII. The basic products were converted to salts which were pharmacologically tested. Compounds X, XVII, XXIII, and XXVII showed anticonvulsant effects and some other neurotropic activities.