Kinetics of alkaline hydrolysis and correlation studies of m- and p-substituted piperidinoethyl phenylcarbamates

Abstract

Kinetics of alkaline hydrolysis have been studied with a series of 15 m- and p-substituted piperidinoethyl phenylcarbamates. The rate constants have been determined at 70, 60, 50, and 40 °C and the activation parameters have been calculated. These values have been correlated with the substituent constants σ, F, R, F, R, π. Validity of the Hammett equation and the Swain-Lupton equation has been confirmed in the series studied and for the p-derivatives, respectively. The lipophilicity parameter π does not correlate with the values found.