Azachalcone Derivatives and Their Bis Substituted Analogs as Novel Antimycobacterial Agents

Abstract

Fifteen novel substituted azachalcone derivatives and their bis substituted analogs were prepared from 3,5-diacetyl-2,6-dimethylpyridine by the Claisen-Schmidt condensation. The influence of the reaction conditions on the yield of mono- and bischalcones was studied to optimize the reaction. Spectral characteristics along with preliminary results of antimycobacterial activity of selected compounds are given.