Author:
Čejka Jan,Horák Zdeněk,Pakhomova Svetlana,Kratochvíl Bohumil,Sedmera Petr,Havlíček Vladimír,Cvak Ladislav,Jegorov Alexandr
Abstract
Pergolide sulfoxide (1), a metabolite of pergolide (2), has been prepared by oxidation of 2 with hydrogen peroxide. Its structure was determined by X-ray diffraction and compared with the structures of related ergot alkaloids. Two molecules of pergolide (S)- and (R)-sulfoxide crystallize with one molecule of water in the orthorhombic space group P212121 with a = 12.216(3) Å, b = 13.733(2) Å, c = 22.186(6) Å, Z = 4, V = 3 722(2) Å3.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
3 articles.
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1. An experimental charge density study of mesulergine hydrochloride, a dopamine agonist;Journal of Chemical Crystallography;2005-01
2. Pergolide mesylate form II;Acta Crystallographica Section C Crystal Structure Communications;2003-09-23
3. A crystallographic investigation of Ergolines;Structural Chemistry;2002