Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta-Reference-Cited by-同舟云学术

Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta

Published:1998 Issue:10 Volume:63 Page:1671-1677
ISSN:0010-0765
Container-title:Collection of Czechoslovak Chemical Communications
language:en
Short-container-title:Collect. Czech. Chem. Commun.

Author:

Pettit George R.,Cichacz Zbigniew A.,Tan Rui,Herald Delbert L.,Melody Noeleen,Hoard Michael S.,Doubek Dennis L.,Hooper John N. A.

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3·10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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