6,11-Dihydrodibenzo[b,e]thiepin-11-yl 3-quinuclidinyl ethers: New potential intidepressants and antihistamine agents-Reference-Cited by-同舟云学术

6,11-Dihydrodibenzo[b,e]thiepin-11-yl 3-quinuclidinyl ethers: New potential intidepressants and antihistamine agents

Published:1988 Issue:8 Volume:53 Page:1806-1811
ISSN:0010-0765
Container-title:Collection of Czechoslovak Chemical Communications
language:en
Short-container-title:Collect. Czech. Chem. Commun.

Author:

Polívka Zdeněk,Metyš Jan,Protiva Miroslav

Abstract

Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-methyl derivative, and further of the methanesulfonates of 2-chloro- and 2-bromo-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 3-quinuclidinol afforded the title ethers I-IV. The 2-methyl compound II (VÚFB-17 088) showed significant antihistamine activity and the 2-chloro compound III (VÚFB-17 089), having antireserpine and anticataleptic activity, proved a potential antidepressant agent.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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