Author:
Lebl Michal,Hrbas Pavel,Škopková Jana,Slaninová Jiřina,Machová Alena,Barth Tomislav,Jošt Karel
Abstract
Deamino-6-carba-oxytocin analogues with modified aromatic amino acid in the position 2 were prepared by stepwise peptide synthesis in solution and cyclization in the last step. Some of the prepared analogues exhibit high and/or specific natriuretic activity. Structural requirements for this type biologic activity are discussed.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
12 articles.
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