7-(3-Substituted amino-2-hydroxypropyl)-8-benzyl-, or -8-phenyltheophyllines
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Published:1982
Issue:5
Volume:47
Page:1339-1345
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ISSN:0010-0765
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Container-title:Collection of Czechoslovak Chemical Communications
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language:en
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Short-container-title:Collect. Czech. Chem. Commun.
Author:
Štibrányi Ladislav,Rybár Alfonz,Jendrichovský Ján,Boženková Lýdia,Kovalčík Vladimír
Abstract
N-Substituted derivatives of 7-(3-amino-2-hydroxypropyl)-8-benzyl- (V), or -8-phenyltheophylline (VI) were prepared by addition of the appropriate amines to 7-epoxypropyl-8-benzyl- (III), or -8-phenyltheophyllines (IV). Compounds III and IV were obtained by alkylation of 8-benzyl-, or 8-phenyltheophyllines with 1-chloro-2,3-epoxypropane. DerivativesV and VI exhibited a peripheral vasodilatation effect in vitro.
Publisher
Institute of Organic Chemistry & Biochemistry
Subject
General Chemistry