Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases-Reference-Cited by-同舟云学术

Synthesis of Aminopropyl Phosphonate Nucleosides with Purine and Pyrimidine Bases

Published:2006 Issue:1 Volume:71 Page:15-34
ISSN:0010-0765
Container-title:Collection of Czechoslovak Chemical Communications
language:en
Short-container-title:Collect. Czech. Chem. Commun.

Author:

Zhou Ding,Lagoja Irene M.,Van Aerschot Arthur,Herdewijn Piet

Abstract

The synthesis and antiviral evaluation of new acyclic phosphonate nucleosides related to HPMPC (Cidofovir) has been described. These aminopropyl phosphonate nucleosides 1-3 have an amino function within either the acyclic chain (series 2 and 3) or as substituent (series 1). Both purine and pyrimidine nucleotide analogues have been synthesized. In contrast to HPMPC the oxygen analogue of 2c, only a weak antiherpes virus activity could be demonstrated for 2b and 2c.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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