Activation of adenylate cyclase from rat renal medulla by some oxytocin analogs
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Published:1980
Issue:4
Volume:45
Page:1132-1136
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ISSN:0010-0765
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Container-title:Collection of Czechoslovak Chemical Communications
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language:en
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Short-container-title:Collect. Czech. Chem. Commun.
Author:
Klenerová Věra,Munclinger Miroslav,Hynie Sixtus,Barth Tomislav,Jošt Karel
Abstract
The ability of carba-analogs of oxytocin to activate adenylate cyclase was followed on the crude enzyme preparation from rat renal medulla. Their stimulating effects on adenylate cyclase activity were in a correlation with their antidiuretic potency. There is discussed the dependence of the affinity of carba-analogs of oxytocin to stimulate adenylate cyclase and their antidiuretic potency on the character of changes in the primary structure of these drugs.
Publisher
Institute of Organic Chemistry & Biochemistry
Subject
General Chemistry