Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analogue - 9-(S)-(2,3-dihydroxypropyl)adenine

Abstract

9-(S)-(2,3-Dihydroxypropyl)adenine, a nucleoside analogue with antiviral activity, inhibits the hydrolysis of S-adenosyl-L-homocysteine catalyzed by rat liver S-adenosyl-L-homocysteine hydrolase (Ki = 3.5 μM; Ki/Km = 5.6 . 10-2). The effect upon the synthesis of the substrate is much less pronounced.