Alkaloids from Corydalis cava (L.) SCHW. et KOERTE

Abstract

From the tubers of Corydalis cava (L.) SCHW. et KOERTE the following alkaloids were isolated: (+)-bulbocapnine, (+)-corydaline, (+)- and (±)-tetrahydropalmatine, (+)- and (±)-thalictricavine, (+)-corybulbine, corycavine, protopine, (+)-corypalmine, (±)- and (+)-isocorypalmine, (+)-corytuberine, (+)-corydine, (+)- and (±)-corycavidine, (+)-canadine, (+)-stylopine, (-)-scoulerine, capnoidine, dehydrocorydaline, corysamine, coptisine; further the following alkaloids not yet described as components of this plant: (+)-tetrahydrocorysamine, allocryptopine, palmatine, berberine, dehydrocorybulbine, dehydrothalictricavine, (+)-α-stylopine methohydroxide and the alkaloid CC2, as well as the new neutral alkaloids dehydroapocavidine, (+)-bulbocapnine methohydroxide, and α-tetrahydrocorysamine methohydroxide. Further the presence of apocavidine, columbamine, jatrorrhizine and magnoflorine was also proved. In the aerial parts (+)-bulbocapnine, (+)-stylopine, protopine, capnoidine, glaucine, domestine alkaloid CC1 (probably dehydrodomestine), predicentrine, isoboldine corydine, coptisine, corysamine and traces of bulbocapnine methohydroxide were found.