Author:
Dobosz Maria,Pitucha Monika,Dybala Izabela,Kozioł Anna E.
Abstract
By the reaction of hydrazide of 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic acid (1) with isocyanates, 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetosemicarbazide derivatives 2 were obtained. Cyclization of these compounds in the presence of 2% NaOH led to the formation of 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives 3, which was confirmed by X-ray analysis of 3b.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis;Archiv der Pharmazie;2021-04-26
2. Synthesis and structure of new 1-cyanoacetyl-4-arylsemicarbazide derivatives with potential anticancer activity;Journal of Molecular Structure;2016-01
3. A one-step synthesis of 4,4'-(methylenedi-4,1-phenylene)bis-[5-(2-thienylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one];Chemistry of Heterocyclic Compounds;2011-06
4. Experimental and theoretical investigations on the keto–enol tautomerism of 4-substituted 3-[1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives;Journal of Molecular Structure;2011-05
5. Synthesis, Experimental and Theoretical Study on the Structure of Some Semicarbazides with Potential Antibacterial Activity;Zeitschrift für Naturforschung B;2011