4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid and Its Derivatives

Abstract

Friedel Crafts reaction of itaconic anhydride (III) with 2,4-difluorobiphenyl (II) afforded unsaturated acid IV which was hydrogenated to give 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (I). A series of functional derivatives and salts of the acid I has been prepared. The antiinflammatory effect of these compounds was compared with that of acid I using selected experimental inflammation models. The analgesic activity in the intraperitoneal irritation test was also evaluated. In the case of (R)-(+)-1-phenylethylamide Vf the ratio of the diastereoisomers was determined by HPLC.