Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds-Reference-Cited by-同舟云学术

Antihistamine Substances. Tricyclic Analogues of N-(4,4-Diphenyl-3-butene-1-yl)nipecotic Acid and Some Related Compounds

Published:1994 Issue:3 Volume:59 Page:667-674
ISSN:0010-0765
Container-title:Collection of Czechoslovak Chemical Communications
language:en
Short-container-title:Collect. Czech. Chem. Commun.

Author:

Šindelář Karel,Šilhánková Alexandra,Urban Jiří,Metyš Jan,Valchář Martin,Polívka Zdeněk

Abstract

Alkylation of ethyl nipecotate with bromides VII - X gave amino esters Ib - Vb. Alkylation of ethyl piperazine-2-carboxylate with 4-bromo-1,1-diphenyl-1-butene afforded compound Vb. Final product Ia - Va were obtained by acid hydrolysis of corresponding esters Ib - Vb. Some of the compounds showed significant antihistamine and antiulcer activities.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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