Solvolysis of some 1-(8α-ergolinyl)-3,3-diethylureas and their salts

Abstract

Nine salts of 1-(8α-ergolinyl)-3,3-diethylurea (II) were prepared and their solubility in water and the stability of the aqueous solutions at 60 and 100 °C were studied. The main product of hydrolysis is 6-methyl-8α-aminoergoline IV. The urethan VII is formed in the ethanolic solution. Both decomposition products are also formed under long-term storage at +5 °C. The course of hydrolysis of N-propyl homologue III is similar. The decomposition of 9,10-didehydro derivative I is much slower under the conditions used.