Author:
Slaninová Jiřina,Lebl Michal,Barth Tomislav,Jošt Karel
Abstract
Five analogues of deamino-1-carba-oxytocin, in which the γ-carboxyl group of glutamine in position 4 had been modified (free acid, monomethylamide, dimethylamide, hydrazide, p-tolylamide), were investigated regarding their uterotonic activity in vitro. The slope of the dose-response curve and the magnitude of the maximum response were compared with those of oxytocin in magnesium-free and 0.5 mM Mg-containing media. In the case of [4-glutamic acid] deamino-1-carba-oxytocin, the RMg2+ value equalled 22. The other compounds had RMg2+ values of 2-3. All the analogues evoked the same maximum response as oxytocin in both the media tested.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
3 articles.
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