Author:
Brtník František,Krojidlo Milan,Barth Tomislav,Jošt Karel
Abstract
Preparation of oxytocin, arginine-vasopressin and its deamino-analogue serves as an example of use of 2,4,6-trimethylbenzyl group for protection of the cysteine sulfur atom in the peptide synthesis. This modified benzyl group is sufficiently stable under conditions of solvolytic removal of common amino-protecting groups and it can be cleaved off under mild conditions with liquid hydrogen fluoride or trifluoromethanesulfonic acid.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
10 articles.
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