Synthesis and Spectral Properties of 1-(6-Methoxy-2-benzothiazolyl)-2-pyridones

Abstract

Substituted 1-(6-methoxy-2-benzothiazolyl)-2-pyridones 5a-5f have been prepared from N-(6-methoxy-2-benzothiazolyl)cyanoacetamide (2) which on reactions with 4-substituted benzaldehydes gives 3-aryl-2-cyano-N-(6-methoxy-2-benzothiazolyl)-2-propenamides 4a-4g. Derivatives 4a-4f were cyclized with malonodinitrile in the presence of piperidine to give the corresponding 2-pyridones 5a-5f. The IR, UV, 1H NMR and mass spectra of the substances synthesized are discussed.