Synthesis and Biological Activity of Four Vasopressin Analogs Modified in Position 3 with β-Thienylalanine

Abstract

Four new analogs of arginine-vasopressin substituted in position 3 with β-thienylalanine were synthesized on chloromethylated resin using Boc strategy and DCC or DCC-HOBt to form peptide bonds. The activity of the agonists is not much different in comparison to the unsubstituted compounds. However, the potency of one of the antagonists is strongly reduced.