Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives

Author:

Lagoja Irene M.,Nauwelaerts Koen,Bal-Mahieu Christine,Pasqualini Michela,Bailly Christian,Herdewijn Piet

Abstract

By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl)amino]benzene derivatives 2 or 1,3-bis[2-iminothiazol-3(2H)-yl]benzene derivatives 3 were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds 2a-2d and 3a-3d were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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