Bromonitriles in Heterocyclic Synthesis. Synthesis and Reactions of Thiazolo[3,2-a]pyrimidines (III)

Abstract

As a continuation of our previous work about the synthesis and properties of thiazolopyrimidines, which are expected to be of biological and medicinal importance, the present work is aimed to synthesize new polyfunctional substituted thiazolo[3,2-a]pyrimidines. Pyrimidine derivatives I were reacted with bromomalononitrile or ethyl bromocyanoacetate at room temperature in ethanol in presence of potassium hydroxide as a basic catalyst followed by refluxing the reaction mixture to give thiazolo[3,2-a]pyrimidines IIa-IId.