Author:
Pal B. C.,Slaninová Jiřina,Barth Tomislav,Trojnar Jerzy,Lebl Michal
Abstract
Nα-Glycyl, diglycyl and triglycyl [2-D and [2-L-p-ethylphenylalanine]oxytocin analogs were synthesized by the solid phase technology utilizing racemic p-ethylphenylalanine. Analogs containing this amino acid of D-configuration were shown to be weak uterotonic antagonists both in vitro and in vivo tests; the compound containing triglycyl residue in position 1 was shown to have prolonged time course of inhibitory action. Analogs containing the L-amino acid were shown to be inhibitors of uterotonic activity of oxytocin in vitro, but uterotonic agonists with prolonged effect in vivo.
Publisher
Institute of Organic Chemistry & Biochemistry
Cited by
2 articles.
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