Potential neuroleptics of the orthopramide series; Synthesis of N-(3-(tert.amino)propyl)-5-sulfamoyl-2-methoxybenzamides-Reference-Cited by-同舟云学术

Potential neuroleptics of the orthopramide series; Synthesis of N-(3-(tert.amino)propyl)-5-sulfamoyl-2-methoxybenzamides

Published:1990 Issue:3 Volume:55 Page:797-808
ISSN:0010-0765
Container-title:Collection of Czechoslovak Chemical Communications
language:en
Short-container-title:Collect. Czech. Chem. Commun.

Author:

Valenta Vladimír,Vlková Marie,Holubek Jiří,Svátek Emil,Metyšová Jiřina,Protiva Miroslav

Abstract

Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert.amino)propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series. Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.

Publisher

Institute of Organic Chemistry & Biochemistry

Subject

General Chemistry

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