Author:
Megges Rudolf,Weiland Jürgen,Schön Rudolf,Repke Heinrich,Repke Kurt R. H.
Abstract
Two ways are shown to transform cardioactive cardenolides into cardenamides [17β-(5-oxo-2,5-dihydropyrrol-3-yl)-5β,14β-androstane derivatives], and their derivatives by replacement of their ring oxygen by N-R. Cardioactivity is strongly decreased by this transformation. The comparatively easily accessible 21-oxocardenamides [17β-(2-maleimidyl)steroids] are strongly thiol reactive and show remarkable anticancer activity.
Publisher
Institute of Organic Chemistry & Biochemistry