Preparation of Unlabelled and [3H]-Labelled Epitestosterone and Its Metabolites

Abstract

Cold as well as [3H]-labelled substrates and metabolites IX - XI, XV, XVI, XX - XXII, XXIV, XXV and XXVIII were prepared by catalytic hydrogenation of epitestosterone (VIII) and ∆1-dehydroepitestosterone (XIII). The key step in the preparation of compound XXVIII was reaction of 3β-tosylates XXVI and XXX with potassium nitrite in dimethyl sulfoxide.