Copper(II) Dihydroxybenzoates; Synthesis and Properties

Abstract

Compounds of composition Cu(2,5-DHB)2 . 4 H2O (DHB, dihydroxybenoate anion) and Cu(2,Y-DHB)2 . 8 H2O (Y = 4 or 6) were prepared as potential antiinflamatory gents with a view of pharmacological screening. The room-temperature magnetic moments allow to classify all compounds into the group of magnetically diluted copper(II) complexes. According the EPR and electronic spectra, the degree of tetragonal distortion increases passing from Cu(2,6-DHB)2 . 8 H2O (III) through Cu(2,4-DHB)2 . 8 H2O (I) to Cu(2,5-DHB)2 . 4 H2O (II. The complexes differ also in the cooperative ordering in their structures. All tested compounds exhibit higher antiinflamatory activities (on dextran edema) than free carboxylic acids. However, their effects were accompanied with relatively high toxicity. Remarkable results were also achieved on evaluating the antipyretic activity.