Author:
SALIMOVA Z.D., ,DODKHOEVA M.F.,
Abstract
The literature review examines the data on the role of folic acid in the human body, especially in women of the reproductive period. An analysis of research studies was conducted to assess the effect of folic acid and folate deficiency on organogenesis and placental formation. In addition, folate deficiency is associated with severe pregnancy complications, including placental abruption, spontaneous miscarriages, intrauterine growth retardation, and preeclampsia. Also, it plays a role in developing congenital malformations of the cardiovascular, nervous, visual and musculoskeletal systems. It was found that with hyperhomocysteinemia, the risk of complications with a self-enhancing cascade of pathological changes during the gestation period increases significantly. In this regard, when planning a pregnancy, it is recommended that all women examine the levels of homocysteine concentration. It is also mandatory to investigate the levels of homocysteine concentration in women with a history of obstetric complications – placental abruption, miscarriage, and the family history of stroke, myocardial infarction and thrombosis in relatives below the age of 45-50 years. Keywords: Folic acid, folates, folate deficiency, hyperhomocysteinemia, pregnancy, miscarriage.
Publisher
Avicenna Tajik State Medical University
Subject
Psychiatry and Mental health
Reference51 articles.
1. 1. Zubtsov YuN, Perevarikhina AA. Soderzhanie folievoy kisloty v ratsione pitaniya studentov vysshikh uchebnykh zavedeniy [The content of folic acid in the diet of university students]. Vestnik OrelGIET. 2017;1:114-8.
2. 2. Karnaukh EV, Plugatareva MV. Folievaya kislota v zhizni cheloveka [Folic acid in human life]. European Student Scientific Journal. 2014;2.
3. O perspektivakh ispol'zovaniya vitaminov i mineralov v profilaktike rannikh poter' beremennosti [On the prospects for the use of vitamins and minerals in the prevention of early pregnancy losses];Gromova;Akusherstvo i ginekologiya,2021
4. 4. Izrailova AS, Agaydarov R D, Aytbaeva AA. Profilaktika vrozhdennykh porokov razvitiya [Prevention of congenital malformations]. Zdorov'e materi i rebyonka. 2016;3:40-3
5. 5. Bogdanova TM, Savinova DS, Davydov IS, Dyomin AS, Kosareva AV. Folievaya kislota, istoriya otkrytiya, teratogennoe vliyanie nedostatochnosti B9 [Folic acid, history of discovery, teratogenic effect of B9 deficiency]. Psikhosomaticheskie i integrativnye issledovaniya. 2018;4:1-6.