Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance
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Published:2024-01-06
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ISSN:1735-5249
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Container-title:Iranian Journal of Allergy, Asthma and Immunology
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Short-container-title:IJAAI
Author:
Dabbaghipour Reza,Ahmadi Elham,Entezam Mona,Farzam Omid Rahbar,Baghbanzadeh Amir,Sichani Ali Saber,Jalilzadeh Nazila,Jafarlou Mahdi,Baradaran Behzad
Abstract
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
Publisher
Knowledge E DMCC