The effect of propranolol on post-accident stress and clinical outcomes of burn patients: a clinical trial

Abstract

Objective:  The hypermetabolic response has undoubtedly evolved to help survive burns, but this physiological response has inconsistent consequences and increases the clinical consequences, such as increased heart work and ultimately its decline, decreased immune system function, risk of  sepsis, increased long-term hospitalization, which increases the mortality of patients. This study aims to examine the effect of propranolol on post-traumatic stress disorder and clinical outcomes in burn patients. Methods:  This was an open-labeled randomized clinical trial in a single center with two parallel groups without placebo control. Propranolol was given 48 hours after starting of resuscitation. Results:  In this study, the burn wound of the patients who used propranolol healed faster. In addition, the administration of propranolol reduced the size of the burning surface, the size of the tissue required skin graft, the rejection rate of skin grafts, and also the length of stay in the hospital. Conclusion:  Using propranolol in treating burns can play an influential role in the recovery of burn patients,  and reduce the post-traumatic stress disorder.