Interferon – Gamma in Health and Disease

Abstract

Interferon-gamma is immunoregulatory cytokine with a vast complexity of functions. Both progressive and suppressive properties of this cytokine class are being evaluated in past decades. The exact prognostic effects of this moiety are being looked at, in the past few years. Based on the physiological significance, the activity from an allergic disease to cancer immunotherapy is being perused all over the world. There is a crucial role of interferon –gamma in CD4- T helper-1 differentiation, activation of interleukins, immunoglobulins and activation of defence cells. Recent years of research has led to unfold the effect of interferon –gamma to the level of improvising the function of stem cells even in dental pulp and reversal of tumorigenic cells. Key words: interferon-gamma, CD4 , immunomodulotor, cancer