Is 8-OHdG a reliable marker in Periodontitis – the sixth complication of Diabetes mellitus?

Abstract

The imbalance between oxidants and antioxidants in favour of oxidants leads to oxidative damage. In diabetes mellitus, the above phenomenon occurs due to an increase in free radicals and a profound reduction in antioxidants. In periodontitis which is the sixth complication of diabetes mellitus, oxidative damage occurs in periodontal tissues. The oxidative damage to DNA results in 8-OHdG (8- hydroxydeoxyguanosine) formation in diabetes mellitus patients as well as in periodontitis patients. 8-OHdG is a stable product and is excreted in tissue fluids such as urine, saliva and gingival crevicular fluid. Here in this review, biochemical marker 8-OHdG and its association with periodontitis, the sixth complication of diabetes mellitus will be discussed. Key words: 8- hydroxy deoxy guanosine, Aggressive periodontitis, Chronic periodontitis, Diabetes Mellitus, Periodontitis,