Affiliation:
1. Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers
2. Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences
3. Central Research Laboratory, Ural State Medical University
Abstract
Introduction. Exposure to lead and cadmium is an important risk factor for the health of workers in copper smelters and refiners. Numerous epidemiological studies have revealed a relationship between exposure to lead and cadmium and the development of hypertension and cardiovascular disease. Material and methods. At the closing stage of the experiment, we registered over 50 characteristics of animals’ health status, including functional, cytological, morphological (with morphometry of certain organs) and biochemical indices. The exposure period accounted for 6 weeks, during which we monitored the general health status of the exposed animals and the control group. Experimental estimates of some of the health indices were used for mathematical modeling of the combined Pb+Cd exposure via Response Surface Methodology. Results. The obtained results were consistent with our earlier conclusions that there are different types of combined Pb+Cd toxicity. The ultimate interaction of toxic agents is determined by what effect is being considered, the level of the effect, and the ratio of the doses. The same toxic mixture can produce a range of interactions, from synergism to antagonism. In this study, we discovered cardiovascular toxicity indices (ECG, BP) to do also suggest that there are different types of combined Pb+Cd toxicity. Most ECG features suggest a synergistic relationship between Pb and Cd, except for P-wave, which amplitude may be interpreted as an indication of Pb-Cd antagonism. Moreover, the antagonistic relationship between Pb and Cd was established with respect to their effects on blood pressure in rats. Conclusion. It is shown that there are different types of lead and cadmium combined cardiovascular toxicity in ionic form in rats.
Publisher
Federal Scientific Center for Hygiene F.F.Erisman
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,General Medicine
Reference26 articles.
1. Hernàndez A.F., Tsatsakis A.M. Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment. Food Chem Toxicol. 2017; 103: 188–93. DOI: https://doi.org/10.1016/j.fct.2017.03.012
2. Directorate-General for Health and Consumers (European Commission). Toxicity and assessment of chemical mixtures. 2013. 50 p. DOI: https://doi.org/10.2772/21444
3. Zholdakova Z.I., Kharchevnikova N.V., Mamonov R.A., Sinitsyna O.O. Methods for estimating the combined effect of substances. Gigiena i sanitariya [Hygiene and Sanitation, Russian journal]. 2012; 2: 86–9. (in Russian)
4. Yuan G., Dai S., Yin Z., Lu H., Jia R., Xu J. et al. Toxicological assessment of combined lead and cadmium: Acute and sub-chronic toxicity study in rats. Food Chem Toxicol. 2014; 65: 260–8. DOI: https://doi.org/10.1016/j.fct.2013.12.041
5. Varaksin A.N., Katsnelson B.A., Panov V.G., Privalova L.I., Kireyeva E.P., Valamina I.E. et al. Some considerations concerning the theory of combined toxicity: a case study of subchronic experimental intoxication with cadmium and lead. Food Chem Toxicol. 2014; 64: 144–56. DOI: https://doi.org/10.1016/j.fct.2013.11.024
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